The European Hotline 116,000 is coordinated by Missing Children Europe (MCE), the European Federation for Missing and Sexually Exploited Children representing 29 NGOs operating in 24 European Union countries and Switzerland. To date, the service is operative in 27 EU Member States. All these countries cooperate with the intent to set up good practices at European level and to facilitate the exchange of interventional procedures more and more effective in combating the disappearance of children and adolescents, Italian and foreign. MCE publishes an annual Report, whose last version dates back to 2014, and further published a practical guide for hotline operators, so that all coutries use common operative procedures.